Clomiphene citrate treatment cycle outcomes of PCOS patients based on basal HS-CRP levels: a cross-sectional study
نویسندگان
چکیده مقاله:
Objective Polycystic ovary syndrome (PCOS) is highly associated with anovulatory infertility, features of the metabolic syndrome, including obesity, insulin resistance and dyslipidemia. Serum concentrations of high sensitive C- reactive protein (hs-CRP) were significantly higher in obese than in non-obese PCOS patients at baseline suggesting that the relationship between elevated hs-CRP levels and obesity. The aim of this study was to evaluate whether cycle day 3 hs-CRP levels before clomiphene citrate (CC) treatment would predict cycle outcomes in women with PCOS. MaterialsAndMethods This cross-sectional study was conducted among 84 infertile women with PCOS who were treated with CC. Based on the exclusion criteriae, cycle outcomes of remaining 66 infertile women with PCOS who were treated with CC were analysed. The hs-CRP levels and insulin resistance indexes were evaluated on cycle day 3 of the CC treatment cycle. The primary outcome measures were number of preovulatory follicles measuring ≥ 17 mm and pregnancy rates. Results The mean±SD age of the patients was 24.0±3.8 years (range 18–36). The mean±SD body mass index (BMI) of the patients was 25.7±4.9 (range 17-43). Fifty patients have developed dominant follicle (75%) and 5 patients have established clinical pregnancy during the study (Clinical pregnancy rate: 7%). The mean±SD baseline hs-CRP, fasting insulin and HOMA-IR values of the patients with and without dominant follicle generation during treatment cycle were 6.42±7.05 and 4.41±2.95, 11.61±6.94 and 10.95±5.65, 2.68±1.79 and 2.41±1.30 respectively (p=0.27, p=0.73, p=0.58). The mean±SD baseline hs-CRP, fasting insulin and HOMA-IR values of the patients with and without clinical pregnancy establishment following treatment cycle were 6.30±2.56 and 5.90±6.57, 11.60±7.54 and 11.44±6.61, 2.42±1.51 and 2.63±1.70 respectively (p=0.89, p=0.95, p=0.79). Conclusion In this study, we did not observe a predictive value of cyle day 3 hs-CRP levels on preovulatory follicle development and pregnancy rates among infertile PCOS patients treated with CC. Also, no relationship between HOMA-IR values and dominant follicle generation or clinical pregnancy establishment has been demonstrated in our study confirming the previous studies emphasizing the neutral effect of metformin utilization before and/or during ovulation induction to pregnancy rates.
منابع مشابه
clomiphene citrate treatment cycle outcomes of pcos patients based on basal hs-crp levels: a cross-sectional study
objective: polycystic ovary syndrome (pcos) is highly associated with anovulatory infertility, features of the metabolic syndrome, including obesity, insulin resistance and dyslipidemia. serum concentrations of high sensitive c- reactive protein (hs-crp) were significantly higher in obese than in non-obese pcos patients at baseline suggesting that the relationship between elevated hs-crp levels...
متن کاملClomiphene Citrate Treatment Cycle Outcomes of Polycystic Ovary Syndrome Patients Based on Basal High Sensitive C-Reactive Protein Levels: A Cross-Sectional Study
BACKGROUND Polycystic ovary syndrome (PCOS) is highly associated with an ovulatory infertility, features of the metabolic syndrome, including obesity, insulin resistance and dyslipidemia. Serum concentrations of high sensitive C-reactive protein (hs-CRP) were significantly higher in obese than in non-obese PCOS patients at baseline, suggesting a relationship between elevated hs-CRP levels and o...
متن کاملA Randomized Clinical Trial on Comparing The Cycle Characteristics of Two Different Initiation Days of Letrozole Treatment in Clomiphene Citrate Resistant PCOS Patients in IUI Cycles
Background There are still many questions about the ideal protocol for letrozole (LTZ) as the commonest aromatase inhibitor (AI) used in ovulation induction. The aim of this study is to compare the ultrasonographic and hormonal characteristics of two different initiation times of LTZ in clomiphene citrate (CC) failure patients and to study androgen dynamics during the cycle. MaterialsAndMethods...
متن کاملInduction of Ovulation with Clomiphene Citrate Versus Clomiphene with Bromocriptine in PCOS Patients with Normal Prolactin: A Comparative Study.
INTRODUCTION Polycystic ovarian syndrome (PCOS) is the main cause of anovulatory infertility. Various combination of drugs have been tried to induce ovulation in PCOS patients with varied result. So, this study was planned to compare the effect of bromocriptine combined with Clomiphene Citrate and Clomiphene Citrate alone, in patients of polycystic ovarian syndrome with normal prolactin level. ...
متن کاملMetformin-letrozole in comparison with Metformin-clomiphene citrate in clomiphene-resistance PCOS patients undergoing IUI
BACKGROUND Polycystic ovary syndrome (PCOS) is associated with approximately 75% of women who suffer from infertility due to anovulation. Additionally, around 20- 25% of anovulatory women with PCOS do not respond at all to clomiphene citrate and are considered to be "clomiphene- resistant". Aromatase inhibitors have been suggested as an alternative treatment to clomiphene as the discrepancy bet...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ذخیره در منابع من قبلا به منابع من ذحیره شده{@ msg_add @}
عنوان ژورنال
دوره 10 شماره 4
صفحات 320- 326
تاریخ انتشار 2017-01-01
با دنبال کردن یک ژورنال هنگامی که شماره جدید این ژورنال منتشر می شود به شما از طریق ایمیل اطلاع داده می شود.
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023